Kontsek P, Karayianni-Vasconcelos G, Kontseková E
Institute of Neuroimmunology, Slovak Academy of Sciences, 845 10 Bratislava, Slovak Republic.
Acta Virol. 2003;47(4):201-15.
The human interferon (IFN) system is the best characterized of all animal IFN systems. Until recently it is thought that all IFNs and IFN-related genes and proteins have been discovered. However, in the last three years, the discovery and characterization of IFNs including IFN-epsilon (IFN-epsilon), IFN-kappa (IFN-kappa) and a novel IFN-lambda (IFN-lambda) family, in particular, substantially changed this opinion. In this article, we attempt to review recent developments in the field of interferon discovery and present an overview of current classification of the human IFN system. Characterization of the constituent parts of the human IFN system including ligands, receptors and players involved in the signal transduction pathway are discussed.
人类干扰素（IFN）系统是所有动物干扰素系统中特征最为明确的。直到最近，人们还认为所有的干扰素以及与干扰素相关的基因和蛋白质都已被发现。然而，在过去三年中，干扰素的发现和特性研究，特别是包括ε干扰素（IFN-ε）、κ干扰素（IFN-κ）和一个新的λ干扰素（IFN-λ）家族的发现，极大地改变了这一观点。在本文中，我们试图回顾干扰素发现领域的最新进展，并概述人类干扰素系统的当前分类。文中还讨论了人类干扰素系统组成部分的特性，包括配体、受体以及信号转导途径中涉及的相关因子。
