Sherwin Trevor, Brookes Nigel H
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Clin Exp Ophthalmol. 2004 Apr;32(2):211-7. doi: 10.1111/j.1442-9071.2004.00805.x.
Keratoconus was first discriminated from other corneal ectatic diseases in 1854. Since that time the morphological characteristics of keratoconic progression have been invaluable in the diagnosis of the condition. The key clinical features used to identify keratoconus have remained essentially the same since the introduction of the slit-lamp biomicroscope. Only relatively recently has the development of computerized corneal topography revolutionized the diagnosis of early keratoconus. Analysis of peer-reviewed literature databases revealed a steady chronological increase in pathological research into the progress of keratoconus. This overview describes the recent advances in our understanding of keratoconic pathology and highlights the interactions within the cornea that may be important in the pathogenesis of this condition.
圆锥角膜于1854年首次从其他角膜扩张性疾病中鉴别出来。自那时起，圆锥角膜进展的形态学特征在该疾病的诊断中具有重要价值。自从裂隙灯生物显微镜问世以来，用于识别圆锥角膜的关键临床特征基本保持不变。直到最近，计算机化角膜地形图的发展才彻底改变了早期圆锥角膜的诊断。对同行评审文献数据库的分析显示，关于圆锥角膜进展的病理学研究在时间上稳步增加。本综述描述了我们对圆锥角膜病理学认识的最新进展，并强调了角膜内可能在该疾病发病机制中起重要作用的相互作用。
