Lennie Terry A
College of Nursing, University of Kentucky, Lexington, KY, USA.
Biol Res Nurs. 2004 Apr;5(4):255-64. doi: 10.1177/1099800404263014.
Food intake and body weight changes in response to induction of acute inflammation were examined in intact cycling females, ovariectomized females, and sham-operated male rats. In intact females, body weight and feeding responses were compared between rats in which inflammation was induced on day of estrus with rats in which inflammation was induced on day of diestrus. Anorexia and weight loss were more severe in the female rats with inflammation induced on estrus day, which coincides with peak serum estrogen levels. In ovariectomized females, inflammation was induced the day after rats received injections of estrogen, progesterone, or sesame oil (vehicle). Males received vehicle injections. Among female rats, the group that received estradiol injections the previous day displayed the most severe anorexia. The least severe anorexia was observed in female rats that received progesterone the previous day. Food intake of female rats that received vehicle injections prior to induction of inflammation was greater than the rats receiving estrogen but less than the rats receiving progesterone. Male rats displayed the most severe anorexia and greatest weight loss. These data suggest that, although females exposed to estradiol prior to induction of acute inflammation display more severe anorexia than those exposed to progesterone, it may be that progesterone attenuates severity of anorexia rather than estrogen solely potentiating severity. Male rats, however, appear to experience the most severe anorexia in response to this form of inflammation.
在完整的周期性雌性大鼠、去卵巢雌性大鼠和假手术雄性大鼠中，研究了急性炎症诱导后食物摄入量和体重的变化。在完整雌性大鼠中，比较了在发情期诱导炎症的大鼠和在动情间期诱导炎症的大鼠的体重和进食反应。发情期诱导炎症的雌性大鼠厌食和体重减轻更严重，这与血清雌激素水平峰值一致。在去卵巢雌性大鼠中，在大鼠注射雌激素、孕酮或芝麻油（赋形剂）后的第二天诱导炎症。雄性大鼠注射赋形剂。在雌性大鼠中，前一天接受雌二醇注射的组表现出最严重的厌食。前一天接受孕酮的雌性大鼠厌食最不严重。在炎症诱导前接受赋形剂注射的雌性大鼠的食物摄入量大于接受雌激素的大鼠，但小于接受孕酮的大鼠。雄性大鼠表现出最严重的厌食和最大程度的体重减轻。这些数据表明，尽管在急性炎症诱导前暴露于雌二醇的雌性大鼠比暴露于孕酮的雌性大鼠表现出更严重的厌食，但可能是孕酮减轻了厌食的严重程度，而不仅仅是雌激素增强了严重程度。然而，雄性大鼠似乎对这种形式的炎症反应表现出最严重的厌食。
