Kismet Kemal, Akay M Turan, Abbasoglu Osman, Ercan Aygün
4th General Surgery Department, Ankara Research and Training Hospital, Ulucanlar, Ankara, Turkey.
Cancer Detect Prev. 2004;28(2):127-42. doi: 10.1016/j.cdp.2003.12.005.
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutic agents in the treatment of pain, inflammation and fever. They may also have a role in the management of cancer prevention, Alzheimer's disease and prophylaxis against cardiovascular disease. These drugs act primarily by inhibiting cyclooxygenase enzyme, which has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Selective COX-2 inhibitors provide potent anti-inflammatory and analgesic effects without the side effects of gastric and renal toxicity and inhibition of platelet function. Celecoxib is a potent COX-2 inhibitor being developed for the treatment of rheumatoid arthritis and osteoarthritis. Chemoprevention is the use of pharmacological or natural agents to prevent, suppress, interrupt or reverse the process of carcinogenesis. For this purpose, celecoxib is being used for different cancer types. The effects of NSAIDs on tumor growth remain unclear, but are most likely to be multifocal. In this article, we reviewed COX-2 selectivity, the pharmacological properties of celecoxib, the use of celecoxib for cancer prevention and the mechanisms of chemoprevention.
非甾体抗炎药（NSAIDs）是治疗疼痛、炎症和发热最广泛使用的治疗药物。它们在癌症预防、阿尔茨海默病管理和心血管疾病预防中也可能发挥作用。这些药物主要通过抑制环氧化酶起作用，环氧化酶有两种同工型，即环氧化酶-1（COX-1）和环氧化酶-2（COX-2）。选择性COX-2抑制剂具有强大的抗炎和镇痛作用，且无胃毒性、肾毒性及抑制血小板功能等副作用。塞来昔布是一种正在开发用于治疗类风湿性关节炎和骨关节炎的强效COX-2抑制剂。化学预防是指使用药理学或天然药物来预防、抑制、中断或逆转致癌过程。为此，塞来昔布正被用于不同类型的癌症。NSAIDs对肿瘤生长的影响尚不清楚，但很可能是多方面的。在本文中，我们综述了COX-2选择性、塞来昔布的药理学特性、塞来昔布在癌症预防中的应用以及化学预防机制。
