Sreedhar Amere Subbarao, Kalmár Eva, Csermely Péter, Shen Yu-Fei
Department of Medical Chemistry, Semmelweis University School of Medicine, Budapest, Hungary.
FEBS Lett. 2004 Mar 26;562(1-3):11-5. doi: 10.1016/s0014-5793(04)00229-7.
The 90 kDa heat shock protein, Hsp90, is a main functional component of an important cytoplasmic chaperone complex, and it is involved in various cellular processes, such as cell proliferation, differentiation and apoptosis. Identification of Hsp90 as a molecular target of various anticancer drugs highlighted its importance from the clinical point of view. Here we summarize the current knowledge of various Hsp90 isoforms regarding their genomic location, molecular evolution, functional differences, differential induction after various environmental stresses and in pathological conditions as well as the growing importance of discriminating between Hsp90 isoforms in clinical practice.
90千道尔顿热休克蛋白（Hsp90）是一种重要的细胞质伴侣蛋白复合体的主要功能成分，它参与多种细胞过程，如细胞增殖、分化和凋亡。Hsp90作为多种抗癌药物的分子靶点被鉴定出来，从临床角度突出了其重要性。在此，我们总结了目前关于各种Hsp90同工型的知识，包括它们的基因组定位、分子进化、功能差异、在各种环境应激和病理条件下的差异诱导，以及在临床实践中区分Hsp90同工型的重要性日益增加。
