Edinboro Charlotte H, Scott-Moncrieff J Catharine, Janovitz Evan, Thacker H Leon, Glickman Larry T
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
J Am Vet Med Assoc. 2004 Mar 15;224(6):879-86. doi: 10.2460/javma.2004.224.879.
To determine whether the increasing prevalence of feline hyperthyroidism is the result of aging of the cat population and whether consumption of canned foods at various times throughout life is associated with increased risk of hyperthyroidism.
Retrospective and case-control studies.
Medical records of 169,576 cats, including 3,570 cats with hyperthyroidism, evaluated at 9 veterinary school hospitals during a 20-year period, and 109 cats with hyperthyroidism (cases) and 173 cats without hyperthyroidism (controls).
Age-adjusted hospital prevalence of hyperthyroidism was calculated by use of Veterinary Medical Database records. On the basis of owners' questionnaire responses, logistic regression was used to evaluate associations between consumption of canned food and development of hyperthyroidism.
Age-specific hospital prevalence of feline hyperthyroidism increased significantly from 1978 to 1997. Overall, consumption of pop-top canned (vs dry) food at various times throughout life and each additional year of age were associated with greater risk of developing hyperthyroidism. In female cats, increased risk was associated with consumption of food packaged in pop-top cans or in combinations of pop-top and non-pop-top cans. In male cats, increased risk was associated with consumption of food packaged in pop-top cans and age.
These findings suggest that the increasing prevalence of feline hyperthyroidism is not solely the result of aging of the cat population and that canned foods may play a role.
确定猫甲状腺功能亢进患病率的增加是否是猫种群老龄化的结果，以及一生中不同时期食用罐头食品是否与甲状腺功能亢进风险增加有关。
回顾性研究和病例对照研究。
169576只猫的病历，其中包括3570只患有甲状腺功能亢进的猫，这些猫在20年期间于9家兽医学院医院接受评估，以及109只患有甲状腺功能亢进的猫（病例）和173只没有甲状腺功能亢进的猫（对照）。
利用兽医医学数据库记录计算年龄调整后的医院甲状腺功能亢进患病率。根据猫主人的问卷回复，采用逻辑回归评估罐头食品消费与甲状腺功能亢进发生之间的关联。
1978年至1997年，特定年龄的猫医院甲状腺功能亢进患病率显著增加。总体而言，一生中不同时期食用易拉罐装罐头（与干粮相比）食品以及每增加一岁，患甲状腺功能亢进的风险就更高。在母猫中，风险增加与食用易拉罐装罐头或易拉罐装与非易拉罐装组合包装的食品有关。在公猫中，风险增加与食用易拉罐装罐头食品和年龄有关。
这些发现表明，猫甲状腺功能亢进患病率的增加并非仅仅是猫种群老龄化的结果，罐头食品可能起到了一定作用。
