关于转基因中转录后加工元件的使用。
On the use of post-transcriptional processing elements in transgenes.
作者信息
Whitelaw C B A, Hiripi L, Farini E, Opsahl M L, Bosze Z
机构信息
Department of Gene Expression and Development, Roslin Institute (Edinburgh), Roslin, Midlothian, EH25 9PS, UK.
出版信息
Transgenic Res. 2004 Feb;13(1):75-9. doi: 10.1023/b:trag.0000017178.79427.2c.
Abstract
RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
摘要
RNA加工事件可调节特定转基因的最终产量。我们评估了一系列RNA元件在乳腺细胞中增强α1-抗胰蛋白酶产生的能力。我们的结果表明，需要对每种构建体设计进行逐案评估，并关注体内基因沉默事件的发生。
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本文引用的文献
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