Bovicelli L, Ghi T, Pilu G, Farina A, Savelli L, Simonazzi G, Calzolari E, Ferlini A, Santini D, Valeri B
Department of Obstetrics and Gynecology, Policlinico S.Orsola-Malpighi, University of Bologna, Italy.
Hum Reprod. 2004 May;19(5):1231-4. doi: 10.1093/humrep/deh211. Epub 2004 Apr 7.
A complete mole coexisting with dichorionic twins was diagnosed by the combined use of sonography and chorionic villus sampling at 10 weeks gestation. The pregnancy resulted in the death of one fetus at 31 weeks from presumed feto-maternal haemorrhage, while the other fetus survived in good condition. A summary of the available literature, combined with this report, reveals a total of seven pregnancies with twins and a coexistent complete mole. Only two out of 14 fetuses survived. Maternal complications included one case of pre-eclampsia and one persistent trophoblastic tumour. Accurate diagnosis of complete mole is possible by genetic analysis of chorionic villi obtained with standard transabdominal sampling. Twins with a coexistent complete mole will usually undergo miscarriage. However, fetal survival is possible and the maternal risks seem limited. A concomitance between gestational trophoblastic disease and the occurrence of feto-maternal haemorrhage is observed.
在妊娠10周时，通过超声检查和绒毛取样联合诊断出完全性葡萄胎与双绒毛膜双胎共存。此次妊娠导致一名胎儿在31周时因推测的胎儿-母体出血死亡，而另一名胎儿状况良好地存活下来。现有文献与本报告相结合显示，共有7例双胎妊娠合并完全性葡萄胎。14名胎儿中仅有2名存活。母体并发症包括1例先兆子痫和1例持续性滋养细胞肿瘤。通过标准经腹取样获得的绒毛进行基因分析，可以准确诊断完全性葡萄胎。合并完全性葡萄胎的双胎通常会流产。然而，胎儿存活是可能的，而且母体风险似乎有限。观察到妊娠滋养细胞疾病与胎儿-母体出血的发生之间存在关联。
