Drossou-Agakidou Vasiliki, Roilides Emmanuel, Papakyriakidou-Koliouska Panagiota, Agakidis Charalampos, Nikolaides Nikolaos, Sarafidis Kosmas, Kremenopoulos Georgios
First Neonatology Department, Aristotle University of Thessaloniki, Hippokration General Hospital, 28 Glinou str., 543 52 Thessaloniki, Greece.
Pediatr Infect Dis J. 2004 Apr;23(4):346-9. doi: 10.1097/00006454-200404000-00014.
To investigate the adverse effects of ciprofloxacin administered to neonates with sepsis on the hematologic indices, the hepatic and renal function and the joints and growth at 1 year follow-up.
In this observational prospective study, 2 groups of septic neonates were studied, 116 neonates who received ciprofloxacin and 100 neonates matched for gestational age and birth weight who did not receive ciprofloxacin. In all neonates the leukocyte and platelet counts as well as the serum concentrations of transaminases, bilirubin, albumin, urea and creatinine were measured before initiation of treatment and on the 10th and 15th to 20th days after treatment initiation. In 77 and 83 infants of the ciprofloxacin and control groups, respectively, the growth at the end of the first year of life was evaluated.
No significant differences between the two groups were found in the hematologic and biochemical indices as well as growth at the end of the first year of life. Also no clinical evidence of arthropathy was observed.
Treatment of neonatal sepsis with ciprofloxacin resulted in no short term hematologic, renal or hepatic adverse effects and did not appear to be associated with clinical arthropathy or growth impairment at 1 year follow-up evaluation.
探讨环丙沙星用于脓毒症新生儿后，在1年随访期内对血液学指标、肝肾功能以及关节和生长发育的不良影响。
在这项前瞻性观察研究中，对两组脓毒症新生儿进行了研究，116例接受环丙沙星治疗的新生儿以及100例胎龄和出生体重匹配但未接受环丙沙星治疗的新生儿。在所有新生儿中，于治疗开始前以及治疗开始后第10天和第15至20天测量白细胞和血小板计数以及转氨酶、胆红素、白蛋白、尿素和肌酐的血清浓度。分别对环丙沙星组和对照组的77例和83例婴儿进行了1岁末生长发育评估。
两组在血液学和生化指标以及1岁末生长发育方面均未发现显著差异。也未观察到关节病的临床证据。
环丙沙星治疗新生儿脓毒症未导致短期血液学、肾脏或肝脏不良反应，且在1年随访评估中似乎与临床关节病或生长发育障碍无关。
