Miron Dan, Torem Moshe, Merom Rivka, Colodner Raul
Pediatric Department A, HaEmek Medical Center, Afula, Israel.
Pediatr Infect Dis J. 2004 Apr;23(4):367-8. doi: 10.1097/00006454-200404000-00022.
In an outbreak of shigellosis in a kibbutz in Northeastern Israel, oral nalidixic acid failed clinically in 35% and microbiologically in 28.4% of 14 children as compared with no clinical and microbiologic failure in 25 children who were treated with oral azithromycin (P < 0.01 and 0.012, respectively). Thus azithromycin could be a suitable alternative to nalidixic acid.
在以色列东北部一个集体农场爆发的志贺氏菌病疫情中，14名儿童口服萘啶酸后，35%的儿童临床治疗失败，28.4%的儿童微生物学治疗失败；相比之下，25名接受口服阿奇霉素治疗的儿童未出现临床和微生物学治疗失败的情况（P值分别<0.01和0.012）。因此，阿奇霉素可能是萘啶酸的合适替代药物。
