Mitra Kaberi, Chowdhury M K
Department of Pathology, RG Kar Medical College, Kolkata 700004.
J Indian Med Assoc. 2003 Aug;101(8):484-5.
Menstrual disorder is one of the most frequently encountered and perplexing conditions in adult women. Dysfunctional uterine haemorrhage (DUH) includes scanty, excessive or irregular bleeding, the primary cause of which is yet to become clear. A total of 100 cases of DUH were studied by histological and histochemical evaluation of endomertium with an object to find out the pathophysiology of DUH. Twenty cases of the similar age group without DUH acted as control. Irregular excessive bleeding was found to be the highest in multiparous women in their 4th decade of life. The material from endometrium was studied by haematoxylin and eosin statin, alcian blue, periodic acid Schiff's reaction and alkaline phosphatase activity. Histological examination of the study group revealed normal endometrium in 66% of cases and abnormal in 34% cases while histochemical behaviour was normal in 54% cases and abnormal in 46% cases. Hormonal imbalance is the chief factor in the pathogenesis of DUH and this abnormal hormonal status can better be revealed by a combined study of histological and histochemical evaluation of endometrium.
月经紊乱是成年女性最常见且令人困惑的病症之一。功能失调性子宫出血（DUH）包括月经量少、过多或不规则出血，其主要病因尚不清楚。本研究通过对子宫内膜进行组织学和组织化学评估，共研究了100例功能失调性子宫出血患者，目的是找出功能失调性子宫出血的病理生理学机制。选取20例年龄相仿但无功能失调性子宫出血的女性作为对照。发现不规则过多出血在40多岁经产妇中最为常见。采用苏木精和伊红染色、阿尔辛蓝染色、过碘酸希夫反应和碱性磷酸酶活性检测等方法对子宫内膜组织进行研究。研究组的组织学检查显示，66%的病例子宫内膜正常，34%异常；而组织化学表现54%正常，46%异常。激素失衡是功能失调性子宫出血发病机制的主要因素，通过对子宫内膜进行组织学和组织化学联合评估能更好地揭示这种异常激素状态。
