[横纹肌肉瘤中脆性组氨酸三联体的表达]
[Fragile histidine triad expression in rhabdomyosarcoma].
作者信息
Wang Shou-li, Yang Guang-hua, Bu Hong, Guo Li-xin, Zhou Qiao, Zhang Hong-ying, Ye Lu
机构信息
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Mar;35(2):176-8.
OBJECTIVE
To study the expression of fragile histidine triad (FHIT) protein in rhabdomyosarcoma(RMS) and the possible mechanisms of its effect on tumor.
METHODS
Immunohistochemical technique(SP) was used to detect the expression of FHIT in 44 cases of RMS and 20 cases of normal skeletal muscles.
RESULTS
Reduced expression of FHIT was 68.2% (30/44) in the cases of RMS, and was 35% (7/20) in the cases of normal skeletal muscles; a significant difference was seen between the two groups(P < 0.05). There was no significant relationship of the expression of FHIT with the sex of the patient and the histological type and grade of the tumor(P > 0.05). However, a significant relationship was observed between the expression of FHIT and the prognosis of the tumor in respect to relapse and metastasis of tumor(P < 0.05).
CONCLUSION
The reduced expression of FHIT may play an important role in the development and progression of rhabdomyosarcoma, and thus may become a new prognostic marker in RMS.
目的
研究脆性组氨酸三联体（FHIT）蛋白在横纹肌肉瘤（RMS）中的表达及其影响肿瘤的可能机制。
方法
采用免疫组织化学技术（SP法）检测44例RMS和20例正常骨骼肌中FHIT的表达。
结果
RMS病例中FHIT表达降低的比例为68.2%（30/44），正常骨骼肌病例中为35%（7/20）；两组间差异有统计学意义（P<0.05）。FHIT的表达与患者性别、肿瘤组织学类型及分级无明显相关性（P>0.05）。然而，FHIT的表达与肿瘤复发和转移的预后密切相关（P<0.05）。
结论
FHIT表达降低可能在横纹肌肉瘤的发生发展中起重要作用，因此可能成为RMS的一个新的预后标志物。
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