Sheppard S V, Gibbs R V, Smith D C
Cardiothoracic Centre, Southampton University Hospitals Trust, Southampton, Hampshire, UK.
Perfusion. 2004 Jan;19(1):7-10. doi: 10.1191/0267659104pf703oa.
Fifty patients undergoing elective coronary revascularisation were prospectively randomised to receive either a leucocyte-depleting or a control filter inserted into the arterial line of the cardiopulmonary bypass (CPB) circuit. The concentration of exhaled nitric oxide (NO) was measured 15 min before and 30 min after CPB using a real-time chemiluminescence analyser (Logan Research, Northampton, UK). The baseline rate of exhaled NO production was 2.14 +/- 0.83 ppb/s in the control group, and 2.58 +/- 0.53 ppb/s in leucocyte-depleted group (p = 0.17). Following CPB, the mean rate of exhaled NO production in the control group had increased by 1.51 +/- 0.45 ppb/s to 3.65 +/- 0.81 ppb/s and in the leucocyte- depletion group had increased by 1.05 +/- 0.45 ppb/s to 3.64 +/- 0.62 ppb/s. The increase in exhaled NO production was significantly lower in the leucocyte depleted group (p = 0.002), indicating that leucocyte depletion suppressed the increase in exhaled NO production seen following CPB.
五十名接受择期冠状动脉血运重建术的患者被前瞻性随机分组，分别在体外循环（CPB）回路的动脉管路中插入白细胞滤器或对照滤器。使用实时化学发光分析仪（英国北安普敦的洛根研究公司）在CPB前15分钟和CPB后30分钟测量呼出一氧化氮（NO）的浓度。对照组呼出NO的基线产生率为2.14±0.83 ppb/秒，白细胞滤除组为2.58±0.53 ppb/秒（p = 0.17）。CPB后，对照组呼出NO的平均产生率增加了1.51±0.45 ppb/秒，达到3.65±0.81 ppb/秒，白细胞滤除组增加了1.05±0.45 ppb/秒，达到3.64±0.62 ppb/秒。白细胞滤除组呼出NO产生的增加明显较低（p = 0.002），表明白细胞滤除抑制了CPB后呼出NO产生的增加。
