Parenti Rosalba, Cicirata Federico
Department of Physiological Sciences, University of Catania, Catania, Italy.
Cerebellum. 2004;3(1):16-20. doi: 10.1080/14734220310017186.
The vertebrate nervous system is one of the main sites where retinoids and related binding proteins play their critical roles. The cerebellum is subjected to the effects of retinoids over its lifetime. The retinoid binding proteins are differently expressed during life: CRBP I, expressed in the adult cerebellum, is possibly involved in plasticity during memory processes. CRABP I, expressed in the embryonic cerebellum, is involved in the development of the organ and in cellular differentiation. In particular, since the expression of CRABP I coincides with earliest cerebellar differentiation, it is probably involved in this critical step, participating in a complex network of regulatory genes expressed in the mes/methencephalon such as Fgf8, Wnt1, En1/2, Pax2/5, Otx2 and Gbx2. Finally, the way for metabolic synchronization of isthmic cell populations and the putative existence of alternative pathways for CRABP I to regulate RA are discussed.
脊椎动物的神经系统是视黄酸及其相关结合蛋白发挥关键作用的主要部位之一。小脑在其整个生命周期中都会受到视黄酸的影响。视黄酸结合蛋白在生命过程中的表达有所不同：在成年小脑中表达的CRBP I可能参与记忆过程中的可塑性。在胚胎小脑中表达的CRABP I参与器官发育和细胞分化。特别是，由于CRABP I的表达与小脑最早的分化同时发生，它可能参与了这一关键步骤，参与了中脑/后脑表达的复杂调控基因网络，如Fgf8、Wnt1、En1/2、Pax2/5、Otx2和Gbx2。最后，讨论了峡部细胞群代谢同步的方式以及CRABP I调节视黄酸的替代途径的可能存在。
