Csatary L K, Gosztonyi G, Szeberenyi J, Fabian Z, Liszka V, Bodey B, Csatary C M
United Cancer Research Institute, Alexandria, VA 22307, USA.
J Neurooncol. 2004 Mar-Apr;67(1-2):83-93. doi: 10.1023/b:neon.0000021735.85511.05.
Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treated with MTH-68/H after the conventional modalities of anti-neoplastic therapies had failed. This treatment resulted in survival rates of 5-9 years, with each patient still living today. Against all odds, each patient resumed a lifestyle that resembles their previous daily routines and enjoys a good quality of life, Each of these patients has regularly received MTH-68/H as their sole form of onco-therapy for a number of years now without interruption.
病毒疗法用于治疗人类肿瘤已有三十多年的历史。MTH - 68/H是新城疫病毒的一种减毒活溶瘤病毒株，是用于治疗不同恶性肿瘤的病毒之一。在此，我们报告了将MTH - 68/H应用于多形性胶质母细胞瘤患者的情况，多形性胶质母细胞瘤是最常见、侵袭性最强的神经外胚层肿瘤，预后较差，平均生存期为六个月至一年。4例晚期高级别胶质瘤患者在传统抗肿瘤治疗方法失败后接受了MTH - 68/H治疗。这种治疗使患者的生存率达到了5至9年，且每位患者至今仍在世。尽管困难重重，但每位患者都恢复了类似于以前日常生活的生活方式，并且生活质量良好。这些患者中的每一位多年来都一直定期接受MTH - 68/H作为他们唯一的肿瘤治疗方式，从未间断。
