Digicaylioglu Murat, Kaul Marcus, Fletcher Lauren, Dowen Robert, Lipton Stuart A
Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Neuroreport. 2004 Apr 9;15(5):761-3. doi: 10.1097/00001756-200404090-00004.
Infection with human immunodeficiency virus (HIV)-1 can lead to neurological complications that range from mild cognitive and motor impairment to HIV-associated dementia (HAD). The mechanism of brain injury and dementia remains poorly understood. Interestingly, post mortem brain specimen from HAD patients and transgenic mice expressing the viral envelope protein gp120 present with similar neuropathological signs. The cytokine erythropoietin (EPO) is clinically used to treat anemia but has also been found to prevent neuronal death due to inflammation or excitotoxicity. Here we show that EPO protects cerebrocortical neurons against apoptosis induced by HIV-1/gp120.
感染人类免疫缺陷病毒1型（HIV-1）可导致神经系统并发症，范围从轻度认知和运动障碍到HIV相关痴呆（HAD）。脑损伤和痴呆的机制仍知之甚少。有趣的是，来自HAD患者的死后脑标本和表达病毒包膜蛋白gp120的转基因小鼠呈现出相似的神经病理学体征。细胞因子促红细胞生成素（EPO）在临床上用于治疗贫血，但也已发现它能预防因炎症或兴奋性毒性导致的神经元死亡。在这里，我们表明EPO可保护大脑皮质神经元免受HIV-1/gp120诱导的细胞凋亡。
