Lazic Stanley E, Grote Helen, Armstrong Richard J E, Blakemore Colin, Hannan Anthony J, van Dellen Anton, Barker Roger A
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK.
Neuroreport. 2004 Apr 9;15(5):811-3. doi: 10.1097/00001756-200404090-00014.
In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wild type control mice, we have shown that cell proliferation in the hippocampus was similar in younger asymptomatic R6/1 mice and wild type controls, but that older R6/1 mice had significantly fewer BrdU cells than controls. Such a decrease in cell proliferation may be relevant to some of the deficits seen in these mice, although further work is needed to prove this.
为了确定慢性神经退行性疾病中是否发生神经发生紊乱，我们在亨廷顿舞蹈病（HD）的R6/1转基因小鼠模型中评估了海马体细胞增殖情况。通过在转基因小鼠和野生型对照小鼠的两个不同时间点（5周和20周）使用BrdU标记分裂细胞，我们发现年轻无症状的R6/1小鼠和野生型对照小鼠海马体中的细胞增殖情况相似，但年老的R6/1小鼠的BrdU阳性细胞明显少于对照小鼠。尽管需要进一步研究来证实，但这种细胞增殖的减少可能与这些小鼠中出现的一些缺陷有关。
