Blakemore Laura J, Trombley Paul Q
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4340, USA.
Neuroreport. 2004 Apr 9;15(5):919-23. doi: 10.1097/00001756-200404090-00037.
Increasing evidence suggests that zinc modulates synaptic transmission in the olfactory bulb and other brain regions. We investigated the sensitivity of AMPA receptors on the bulb's two primary neuronal populations to several concentrations of zinc. Zinc (30-1000 microM) was coapplied to mitral/tufted cells and interneurons during AMPA-evoked currents, and current responses (potentiation, inhibition, no effect) were analyzed. Both neuronal populations expressed zinc-sensitive and zinc-insensitive AMPA receptors. However, the frequency and magnitude of zinc's effects varied with cell type. In addition, zinc did not always have biphasic effects at AMPA receptors (potentiation at low concentrations; inhibition at high concentrations), as reported in other brain regions. Zinc's diverse effects suggest that zinc may alter odor information processing by differential modulation of excitatory circuits.
越来越多的证据表明，锌可调节嗅球及其他脑区的突触传递。我们研究了嗅球中两种主要神经元群体上的AMPA受体对几种锌浓度的敏感性。在AMPA诱发电流期间，将锌（30 - 1000微摩尔）与二尖瓣/簇状细胞和中间神经元共同施加，并分析电流反应（增强、抑制、无影响）。两种神经元群体均表达锌敏感和锌不敏感的AMPA受体。然而，锌作用的频率和幅度因细胞类型而异。此外，与其他脑区报道的情况不同，锌对AMPA受体并不总是具有双相作用（低浓度时增强；高浓度时抑制）。锌的多种作用表明，锌可能通过对兴奋性回路的差异调节来改变气味信息处理。
