Chauhan Sandeep, Das Sambhu N, Bisoi Akshay, Kale Shailaja, Kiran Usha
Department of Cardiac Anesthesia, All India Institute of Medical Sciences, New Delhi, India.
J Cardiothorac Vasc Anesth. 2004 Apr;18(2):141-3. doi: 10.1053/j.jvca.2004.01.016.
This study compared the efficacy of aminocaproic acid and tranexamic acid in reducing postoperative blood loss, as well as blood and blood product requirements in children with cyanotic congenital heart disease.
A prospective randomized study.
Cardiac center of a tertiary care, referral hospital.
One hundred fifty children in the age group of 2 months to 14.5 years with cyanotic congenital heart disease undergoing corrective surgery on cardiopulmonary bypass (CPB).
Patients were randomized into 3 groups. Group A was given aminocaproic acid in a dose of 100 mg/kg after anesthetic induction, 100 mg/kg on CPB and 100 mg/kg after protamine. Group T was given tranexamic acid, 10 mg/kg, after anesthetic induction, 10 mg/kg on CPB, and 10 mg/kg after protamine. Group C was the control group.
Control group had the longest sternal closure time, maximum blood loss at 24 hours, and maximum requirements of blood and blood products. Among the 2 groups given antifibrinolytics, there was no significant difference in postoperative blood loss, blood and product requirement, and reexploration rates.
Aminocaproic acid and tranexamic acid are equally effective in reducing postoperative blood loss, as well as blood and blood product requirements in children with cyanotic heart disease undergoing corrective surgery as compared with the control group.
本研究比较了氨甲环酸和氨基己酸在减少紫绀型先天性心脏病患儿术后失血以及血液和血液制品需求方面的疗效。
一项前瞻性随机研究。
一家三级转诊医院的心脏中心。
150名年龄在2个月至14.5岁之间、患有紫绀型先天性心脏病且正在接受体外循环（CPB）矫正手术的儿童。
将患者随机分为3组。A组在麻醉诱导后给予100mg/kg的氨基己酸，体外循环期间给予100mg/kg，鱼精蛋白注射后给予100mg/kg。T组在麻醉诱导后给予10mg/kg的氨甲环酸，体外循环期间给予10mg/kg，鱼精蛋白注射后给予10mg/kg。C组为对照组。
对照组的胸骨关闭时间最长，24小时失血量最大，血液和血液制品的需求量最大。在给予抗纤溶药物的两组中，术后失血量、血液和制品需求量以及再次手术率没有显著差异。
与对照组相比，氨甲环酸和氨基己酸在减少接受矫正手术的紫绀型心脏病患儿术后失血以及血液和血液制品需求方面同样有效。
