Johnson Z, Hayes C, Dack P
Eastern Health Board, Regional Drug Unit, Dr Steevens Hospital, Dublin 8, Ireland.
Pharmacoepidemiol Drug Saf. 1997 Sep;6(5):337-45. doi: 10.1002/(SICI)1099-1557(199709/10)6:5<337::AID-PDS298>3.0.CO;2-P.
To develop a method for comparing the proportion of patients on any drug or group of drugs for individual GP patient panels in Ireland, taking account of the age and sex structure of the panel.
Calculations based on prescribing data for the fourth-quarter of 1995 supplied by the Irish General Medical Services Payments Board for the Eastern Health Board area.Setting-Five hundred and fifty Irish general practices serving 355,000 persons entitled to free medical care under the General Medical Services Scheme in the Eastern Health Board area (28% of the population).
Weightings for number of persons prescribed each of four drug groups, and all drugs combined, for 22 age/sex groupings, leading to a single age/sex adjusted prescribing index-the standardized prescribing ratio (SPR) for each GPs practice population.
The SPRs showed a large amount of variation from the average figure of 100 for practices of 1000 or more patients for all drugs and for each of the four drug groups studied: all drugs 54-125, antibiotics 52-165, H(2) antagonists/proton pump inhibitors 38-197, antidepressants 13-213 and thyroxine 33-175. Practices with above average SPRs for all drugs, antibiotics and H(2) antagonists/proton pump inhibitors were significantly larger than those with below-average SPRs. Practices with below average SPRs for thyroxine were significantly larger than those with above-average SPRs.
The SPR provides a useful age/sex adjusted method of comparing prescribing between GPs and it can be applied to any drug or group of drugs.
制定一种方法，用于比较爱尔兰各全科医生（GP）患者群体中使用任何一种药物或一组药物的患者比例，同时考虑到患者群体的年龄和性别结构。
基于爱尔兰东部卫生委员会地区一般医疗服务支付委员会提供的1995年第四季度处方数据进行计算。背景——爱尔兰东部卫生委员会地区有550家全科诊所，为35.5万名有权享受一般医疗服务计划免费医疗的人员提供服务（占人口的28%）。
针对22个年龄/性别分组，计算四个药物组中每组以及所有药物组合的处方人数权重，得出每个全科医生诊所人群的单一年龄/性别调整处方指数——标准化处方率（SPR）。
对于所有药物以及所研究的四个药物组中的每一组，患者人数在1000人及以上的诊所，其SPR与平均数值100相比存在很大差异：所有药物为54 - 125，抗生素为52 - 165，H₂拮抗剂/质子泵抑制剂为38 - 197，抗抑郁药为13 - 213，甲状腺素为33 - 175。所有药物、抗生素以及H₂拮抗剂/质子泵抑制剂的SPR高于平均水平的诊所，显著大于SPR低于平均水平的诊所。甲状腺素SPR低于平均水平的诊所，显著大于SPR高于平均水平的诊所。
SPR为比较全科医生之间的处方情况提供了一种有用的年龄/性别调整方法，并且可应用于任何一种药物或一组药物。
