心肌梗死与口服避孕药：英格兰和苏格兰的一项回顾性病例对照研究（“MICA”研究）

Myocardial infarction and oral contraceptives, a retrospective case control study in England and Scotland ('MICA' Study).

作者信息

Dunn N R, Thorogood M, de Caestecker L, Mann R D

机构信息

Drug Safety Research Unit, Bursledon Hall, Southampton SO31 1AA, UK.

出版信息

Pharmacoepidemiol Drug Saf. 1997 Jul;6(4):283-9. doi: 10.1002/(SICI)1099-1557(199707)6:4<283::AID-PDS270>3.0.CO;2-F.

DOI:10.1002/(SICI)1099-1557(199707)6:4<283::AID-PDS270>3.0.CO;2-F

PMID:15073780

Abstract

Recent studies have shown that modern (third generation), oral contraceptives (OC) are associated with an increased incidence of venous thromboembolic disease compared to older (second generation), OC. It is not known, however, whether this association is also true for arterial thrombosis, in particular myocardial infarction. In fact, it has been suggested that third generation OC may even be protective against myocardial infarction (MI), compared to second generation OC. The protocol for a multicentre case-control study, involving the whole of England and Scotland, is described. Cases will be female patients aged 16-44 years, who suffered an MI between 1.10.93 and 1.10.95. Controls will be drawn from the community, using the GP list, to which the case belonged. Odds ratios will be calculated primarily to compare current users of third generation OC with current users of second generation OC.

摘要

最近的研究表明，与 older（第二代）口服避孕药（OC）相比，modern（第三代）口服避孕药与静脉血栓栓塞性疾病的发病率增加有关。然而，尚不清楚这种关联对于动脉血栓形成，尤其是心肌梗死是否也成立。事实上，有人提出，与第二代 OC 相比，第三代 OC 甚至可能对心肌梗死（MI）具有保护作用。本文描述了一项涉及整个英格兰和苏格兰的多中心病例对照研究方案。病例将为年龄在 16 - 44 岁之间、在 1993 年 10 月 1 日至 1995 年 10 月 1 日期间发生心肌梗死的女性患者。对照将从病例所属的全科医生名单中抽取社区人群。主要计算优势比，以比较第三代 OC 的当前使用者与第二代 OC 的当前使用者。