Barker K A, Harper B, Hughes I E
J Pharm Pharmacol. 1977 Mar;29(3):129-34. doi: 10.1111/j.2042-7158.1977.tb11268.x.
The ratio (expressed in log10 units) of the equieffective concentrations of (+)- and (-)-noradrenaline has been measured in a variety of isolated tissues in the presence of cocaine (1 x 10(-5) M), tropolone (3 x 10(-5) M) and (+/-)-propranolol (5 x 10(-7) to 5 x 10(-5) M). The values obtained fall into 3 distinct and statistically different groups. Firstly, a high group comprising (mean +/- s.e.) mouse vasdeferens (2-78 +/- 0-04), rabbit duodenum (2-91 +/- 0-07) and ileum (2-86 +/- 0-05). Secondly a middle group comprising rabbit vas deferens (2-54 +/- 0-04), bladder neck muscle (2-56 +/- 0-07) and spleen 2-50 +/- 0-02), guinea-pig vas deferens (2-55 +/- 0-10) and bladder neck muscle (2-48 +/- 0-13) and rat deferens (2-40 +/- 0-08) and thirdlya low group comprising the bladder detrusor muscle from both the rabbit (2-08 +/- 0-08) and the guinea-pig (2-07 +/- 0-04). Under the same conditions measurement of pA2 values for phentolamine and piperoxan against noradrenaline gave the following values in rat vase deferens (8-22 +/- 0-07 and 6-72 +/- 0-03 respectively) and mouse vas deferens (8-31 +/- 0-05 and 6-53 +/- 0-07 respectively). The results are discussed in relation to other findings conderning the nature of the alpha-adrenoreceptor in these tissues. In spite of the absence of any significant difference between the potency of the alpha-adrenoreceptor blocking agents in the two species it is suggested that alpha-adernoreceptors may not belong to a single homogenous population but may vary in their characteristics from tissue to tissue.
在存在可卡因（1×10⁻⁵ M）、托酚酮（3×10⁻⁵ M）和（±）-普萘洛尔（5×10⁻⁷至5×10⁻⁵ M）的情况下，已在多种离体组织中测量了（+）-和（-）-去甲肾上腺素等效浓度的比值（以log₁₀单位表示）。获得的值分为3个不同且具有统计学差异的组。首先，高值组包括（均值±标准误）小鼠输精管（2.78±0.04）、兔十二指肠（2.91±0.07）和回肠（2.86±0.05）。其次是中值组，包括兔输精管（2.54±0.04）、膀胱颈肌（2.56±0.07）和脾脏（2.50±0.02）、豚鼠输精管（2.55±0.10）和膀胱颈肌（2.48±0.13）以及大鼠输精管（2.40±0.08），第三是低值组，包括兔（2.08±0.08）和豚鼠（2.07±0.04）的膀胱逼尿肌。在相同条件下，在大鼠输精管（分别为8.22±0.07和6.72±0.03）和小鼠输精管（分别为8.31±0.05和6.53±0.07）中测量了酚妥拉明和哌罗克生对去甲肾上腺素的pA₂值。结合关于这些组织中α-肾上腺素能受体性质的其他发现对结果进行了讨论。尽管两种物种中α-肾上腺素能受体阻断剂的效力没有任何显著差异，但有人认为α-肾上腺素能受体可能不属于单一的同质群体，而是其特性可能因组织而异。
