Nagumo S, Matuda M, Kuroda M
Center for Adult Diseases, Osaka.
Rinsho Byori. 1992 Jul;40(7):728-35.
Cytologic examinations of voided urine were reviewed for 82 cases of invasive or noninvasive papillary carcinoma and 25 cases of carcinoma in situ of the urinary bladder. Five of the 82 cases of invasive or noninvasive papillary carcinoma and 3 of the 25 cases of carcinoma in situ were asymptomatic, and malignancy was detected only by urinary cytology. Urinary cytology was positive in 18.5% of the Grade 1, 33.3% of the Grade 2, 75% of the Grade 3 noninvasive carcinomas and in 77.8% of the invasive carcinomas. However, all 25 cases of carcinoma in situ gave positive cytologic results. Malignant cells found in Grade 1 noninvasive papillary carcinoma were slightly atypic in shape. Their nuclei were small but showed mild to moderate hyperchromasia. These malignant cells appeared in small clusters but the number of clusters were few. In Grade 2 or 3 noninvasive papillary carcinoma, malignant cells appeared in small clusters or isolated single cells. Their nuclei were irregular in shape and showed moderate to marked hyperchromasia. In invasive carcinoma and carcinoma in situ, many malignant cells with marked atypia were observed, but in carcinoma in situ, the background of the specimens was clean.
对82例浸润性或非浸润性乳头状癌及25例膀胱原位癌患者的尿液脱落细胞学检查进行了回顾性分析。82例浸润性或非浸润性乳头状癌中有5例、25例原位癌中有3例无症状，仅通过尿液细胞学检查发现恶性病变。1级非浸润性癌尿液细胞学阳性率为18.5%，2级为33.3%，3级非浸润性癌为75%，浸润性癌为77.8%。然而，25例原位癌的细胞学检查结果均为阳性。1级非浸润性乳头状癌中发现的恶性细胞形态轻度异型，核小，但有轻度至中度深染。这些恶性细胞呈小簇状出现，但簇数较少。在2级或3级非浸润性乳头状癌中，恶性细胞呈小簇状或单个散在出现，核形不规则，有中度至明显深染。在浸润性癌和原位癌中，观察到许多异型明显的恶性细胞，但原位癌标本背景干净。
