通过电感耦合等离子体原子发射光谱法比较钆双胺（欧乃影）与钆贝葡胺（普美显）在人体骨组织中的潴留情况。
Comparison of Gd DTPA-BMA (Omniscan) versus Gd HP-DO3A (ProHance) retention in human bone tissue by inductively coupled plasma atomic emission spectroscopy.
作者信息
Gibby Wendell A, Gibby Krissa A, Gibby W Andrew
机构信息
Riverwoods Advanced Imaging Center, Provo, Utah 84604, USA.
出版信息
Invest Radiol. 2004 Mar;39(3):138-42. doi: 10.1097/01.rli.0000112789.57341.01.
RATIONALE AND OBJECTIVES
Human bone tissue was collected following administration of a clinical dose of gadolinium chelate (0.1 mmol per kg) to patients undergoing hip joint replacement surgery to determine if measurable differences in Gd deposition occur between 2 widely available magnetic resonance contrast agents.
MATERIALS AND METHODS
Gd HP-DO3A (ProHance), Gd DTPA-BMA (Omniscan), and an age-matched control population without history of gadolinium chelate administration were compared. Bone samples were collected fresh, placed in refrigeration, and subsequently frozen. Tissue digestion was performed using a microwave tissue digester and concentrated nitric acid. A method of tissue analysis was created for gadolinium using inductivity coupled plasma atomic emission spectroscopy (ICP-AES).
RESULTS
Tissue retention was 1.18 +/- .787 microg Gd/g bone (N = 10) for Omniscan and 0.466 +/- .387 microg Gd/g bone (N = 8) for ProHance measured by ICP-AES.
CONCLUSION
Omniscan (Gd DTPA-BMA) left 2.5 times more Gd behind in bone than did ProHance (Gd HP-DO3A).
原理与目的
在接受髋关节置换手术的患者中给予临床剂量的钆螯合物（每千克0.1毫摩尔）后收集人骨组织，以确定两种广泛使用的磁共振造影剂之间钆沉积是否存在可测量的差异。
材料与方法
比较了钆布醇（普美显）、钆喷酸葡胺（欧乃影）以及无钆螯合物给药史的年龄匹配对照人群。新鲜采集骨样本，冷藏后冷冻。使用微波组织消解仪和浓硝酸进行组织消化。使用电感耦合等离子体原子发射光谱法（ICP-AES）建立了一种钆组织分析方法。
结果
通过ICP-AES测量，欧乃影的组织潴留量为1.18±0.787微克钆/克骨（N = 10），普美显为0.466±0.387微克钆/克骨（N = 8）。
结论
欧乃影（钆喷酸葡胺）在骨中留下的钆比普美显（钆布醇）多2.5倍。
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