创伤后应激障碍（PTSD）的缓解：通过戴维森创伤量表、临床总体印象量表和临床医生施测的PTSD量表评估舍曲林的效果。
Remission in post-traumatic stress disorder (PTSD): effects of sertraline as assessed by the Davidson Trauma Scale, Clinical Global Impressions and the Clinician-Administered PTSD scale.
作者信息
Davidson Jonathan R T
机构信息
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA.
出版信息
Int Clin Psychopharmacol. 2004 Mar;19(2):85-7. doi: 10.1097/00004850-200403000-00005.
Rates of remission were examined in two controlled 12-week studies of sertraline and placebo for post-traumatic stress disorder (PTSD). The performance of three scales was evaluated: the self-rated Davidson Trauma Scale (DTS), and two interviewer scales: the Clinician Administered PTSD Scale (CAPS) and Clinical Global Impressions (CGI). Sertraline proved significantly superior to placebo with respect to remission on all three ratings. Rates of remission were very similar for all scales, ranging from 23.1-26.3% for sertraline and 13.9-14.9% for placebo. Traditional thresholds for the CAPS and DTS were tested relative to the CGI and to each other. The CAPS and DTS thresholds of < 20 and < 18 were found to be valid.
在两项为期12周的对照研究中，对舍曲林和安慰剂治疗创伤后应激障碍（PTSD）的缓解率进行了检查。评估了三个量表的表现：自评的戴维森创伤量表（DTS），以及两个访谈者量表：临床医生评定的PTSD量表（CAPS）和临床总体印象（CGI）。在所有三项评分的缓解方面，舍曲林被证明显著优于安慰剂。所有量表的缓解率非常相似，舍曲林的缓解率在23.1%-26.3%之间，安慰剂的缓解率在13.9%-14.9%之间。相对于CGI以及彼此之间，对CAPS和DTS的传统阈值进行了测试。发现CAPS和DTS阈值<20和<18是有效的。
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