Casper Corey, Redman Mary, Huang Meei-Li, Pauk John, Lampinen Thomas M, Hawes Stephen E, Critchlow Cathy W, Morrow Rhoda Ashley, Corey Lawrence, Kiviat Nancy, Wald Anna
Department of Medicine, The University of Washington, Seattle 98122, USA.
J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):233-8. doi: 10.1097/00126334-200403010-00003.
Human herpesvirus-8 (HHV-8) is frequently detected in oropharyngeal secretions from HIV-infected men who have sex with men (MSM), and contact with saliva may be an important mode of HHV-8 transmission. A total of 196 MSM were followed over 2 years to determine the correlates of HHV-8 oropharyngeal shedding. A total of 134 (68%) of 196 participants were HHV-8 seropositive upon enrollment, and 9 (15%) of 62 participants seroconverted to HHV-8 during follow-up. HHV-8 DNA was detected in 43 (22%) of 196 participants: 39 (27%) of 134 HHV-8 seropositive, 4 (8%) of 53 HHV-8 seronegative, and 5 (56%) of 9 seroconverters to HHV-8. HHV-8 was detected in 101 (15%) of 696 total oral specimens: 84 (17%) of 481 samples from HHV-8-seropositive men, 6 (3%) of 180 samples from HHV-8-seronegative men, and 11 (31%) of 35 samples from seroconverters. Using adjusted marginal structural models, HHV-8 shedding was higher in men not receiving highly active antiretroviral therapy (odds ratio 2.4, 95% CI 1.0-6.0, P = 0.06), with CD4 counts > 200 cells/mm (odds ratio 4.8, 95% CI 1.0-22.8, P = 0.05), or with detectable oral leukocyte esterase (odds ratio 5.0, 95% CI 2.0-12.5, P < 0.01). CD4 count, antiretroviral therapy, and oral inflammation may influence HHV-8 oropharyngeal shedding.
人类疱疹病毒8型（HHV - 8）在与男性发生性行为的艾滋病毒感染男性（男男性行为者）的口咽分泌物中经常被检测到，接触唾液可能是HHV - 8传播的一种重要方式。对196名男男性行为者进行了为期2年的跟踪，以确定HHV - 8口咽脱落的相关因素。196名参与者中共有134名（68%）在入组时HHV - 8血清学呈阳性，62名参与者中有9名（15%）在随访期间血清转化为HHV - 8。196名参与者中有43名（22%）检测到HHV - 8 DNA：134名HHV - 8血清学阳性者中有39名（27%），53名HHV - 8血清学阴性者中有4名（8%），9名血清转化为HHV - 8者中有5名（56%）。在总共696份口腔标本中有101份（15%）检测到HHV - 8：481份来自HHV - 8血清学阳性男性的样本中有84份（17%），180份来自HHV - 8血清学阴性男性的样本中有6份（3%），35份来自血清转化者的样本中有11份（31%）。使用调整后的边际结构模型，未接受高效抗逆转录病毒治疗的男性中HHV - 8脱落率更高（比值比2.4，95%可信区间1.0 - 6.0，P = 0.06），CD4细胞计数>200个细胞/mm³者（比值比4.8，95%可信区间1.0 - 22.8，P = 0.05），或口腔白细胞酯酶可检测者（比值比5.0，95%可信区间2.0 - 12.5，P < 0.01）。CD4细胞计数、抗逆转录病毒治疗和口腔炎症可能影响HHV - 8口咽脱落。
