Yamamoto A, Shikada K, Tanaka S
Shiraoka Research Station of Biological Science, Nissan Chemical Ind., Ltd., Saitama, Japan.
Jpn J Pharmacol. 1992 May;59(1):129-32. doi: 10.1254/jjp.59.129.
The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. Isoproterenol and aminophylline non-selectively inhibited both the contraction evoked by vagus nerve- and that by transmural field-stimulation, but had no effect on the response induced by exogenously applied acetylcholine. Hydrocortisone and potassium channel openers, NIP-121 and cromakalim, preferentially inhibited vagus nerve-mediated response. These results suggest that anti-asthma drugs may have an ability to inhibit neurally-mediated contraction in the guinea pig trachea.
在离体豚鼠气管中，研究了抗哮喘药物异丙肾上腺素、氨茶碱和氢化可的松以及钾通道开放剂对电刺激或外源性应用乙酰胆碱诱导的收缩的影响。异丙肾上腺素和氨茶碱非选择性地抑制迷走神经诱发的收缩以及经壁场刺激诱发的收缩，但对外源性应用乙酰胆碱诱导的反应无影响。氢化可的松和钾通道开放剂NIP - 121及克罗卡林优先抑制迷走神经介导的反应。这些结果表明，抗哮喘药物可能具有抑制豚鼠气管神经介导收缩的能力。
