Tan Grace, Samson Ignace, De Wever Ivo, Goffin Jan, Demaerel Philippe, Van Gool Stefaan W
Department of Pediatrics, Leuven Catholic University, Leuven, Belgium.
J Pediatr Orthop B. 2004 Mar;13(2):123-6. doi: 10.1097/00009957-200403000-00012.
When Langerhans cell histiocytosis (LCH) occurs at critical sites, such as in the cervical spine, there is a substantial risk for morbidity. Therefore, reports on clinical experiences with those patients remain important. We summarize the history of four patients with unifocal LCH at the cervical spine. All four patients received a biopsy to prove the histopathological diagnosis of LCH by demonstration of CD1a+cells. They were treated with oral prednisolone. All patients recovered completely and kept a normal function of the cervical spine. No reactivation of the disease occurred with an observation time of 3.4-7.3 years. This report contributes to the clinical experience for the treatment of LCH at critical sites.
当朗格汉斯细胞组织细胞增多症（LCH）发生在关键部位，如颈椎时，存在较高的发病风险。因此，关于这些患者的临床经验报告仍然很重要。我们总结了4例颈椎单灶性LCH患者的病史。所有4例患者均接受了活检，通过显示CD1a+细胞来证实LCH的组织病理学诊断。他们接受了口服泼尼松龙治疗。所有患者均完全康复，颈椎功能保持正常。在3.4至7.3年的观察期内，疾病未复发。本报告为关键部位LCH的治疗提供了临床经验。
