Nanobashvili Avtandil, Woldbye David P D, Husum Henriette, Bolwig Tom G, Kokaia Merab
Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A-11, University Hospital, S-221 84 Lund, Sweden.
Neuroreport. 2004 Feb 9;15(2):339-43. doi: 10.1097/00001756-200402090-00026.
Neuropeptide Y (NPY) has been implicated in antiepileptic action in different in vivo and in vitro epilepsy models in rats and mice. Both Y2 and Y5 receptors could mediate the seizure-suppressant effect of NPY. However, lack of selective ligands precluded previous studies from conclusively evaluating the role of Y5 receptors in anti-epileptiform action of NPY. In the present study, using the new highly selective Y5 receptor antagonist, CGP71683A, and agonist, [cPP]hPP, we show that the Y5 receptor subtype is centrally involved in NPY-induced suppression of spontaneous epileptiform (interictaform) bursting in the CA3 area of rat hippocampal slices. This novel finding underscores the importance of Y5 receptors as a potential target for future antiepileptic therapy, particularly, for interictal components of temporal lobe epilepsy.
神经肽Y（NPY）在大鼠和小鼠的不同体内和体外癫痫模型中均具有抗癫痫作用。Y2和Y5受体均可介导NPY的癫痫抑制作用。然而，由于缺乏选择性配体，以往的研究无法最终评估Y5受体在NPY抗癫痫样作用中的作用。在本研究中，我们使用新型高选择性Y5受体拮抗剂CGP71683A和激动剂[cPP]hPP，发现Y5受体亚型在NPY诱导的大鼠海马切片CA3区自发性癫痫样（发作间期样）爆发抑制中起核心作用。这一新发现强调了Y5受体作为未来抗癫痫治疗潜在靶点的重要性，特别是对于颞叶癫痫的发作间期成分。
