Perlík F
Farmakologický ústav 1. LF UK Praha.
Cas Lek Cesk. 2004;143(2):110-3.
Adverse drug reactions represent a common clinical problem. They are partly induced by a large variability in drug response, which results from the complex interplay between pharmacokinetics, pharmacodynamics and other disease-associated factors. The review describes metabolic changes caused by polymorphism in the cytochrome P450 and gives examples of induction and inhibition of this enzyme system in relation to adverse drug interaction. From the clinical point of view, attention should be paid especially to antidiabetics, anticoagulants and phenytoin. Therapeutic drug monitoring and genetic-based individualization of the therapy with polymorphically metabolized drugs with narrow therapeutic range can contribute to the decreased incidence of adverse drug reactions.
药物不良反应是一个常见的临床问题。它们部分是由药物反应的巨大变异性引起的，这种变异性源于药代动力学、药效学和其他疾病相关因素之间的复杂相互作用。这篇综述描述了细胞色素P450多态性引起的代谢变化，并给出了该酶系统诱导和抑制与药物不良相互作用相关的例子。从临床角度来看，尤其应关注抗糖尿病药物、抗凝剂和苯妥英。对治疗窗窄的多态性代谢药物进行治疗药物监测和基于基因的个体化治疗，有助于降低药物不良反应的发生率。
