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[糖皮质激素在自身免疫性疾病肺部病变和贫血诊断中的可能应用]

[Possible use of glucocorticoids in the diagnosis of lung lesions and anemia in autoimmune diseases].

作者信息

Parizhskiĭ Z M

出版信息

Klin Med (Mosk). 1992 Feb;70(2):40-2.

PMID:1507817
Abstract

The author described a new pattern of the diagnosis of autoimmune processes in the lungs based on the results of a short-term pharmacological load with glucocorticoids (prednisolone, 30 mg per day for 7-10 days) and the successive evaluation of the X-ray picture time-course in the lungs in the frontal roentgenographic view before and after the load. He accounted for the alteration in the number and size of infiltrations and foci as well as the contents of the fluid in the pleura and interlobular fissures. The usage of the load proposed made it possible to reduce the terms and increase the preciseness of the diagnosis of pulmonary autoimmune conditions and to define the practicability of prolongation of the glucocorticoid treatment. Glucocorticoid load technique originated with the author permitted one to establish the autoimmune nature of anemia with regard to its tendency towards the regression and thus to define the policy of its further treatment as well as to differentiate autoimmune anemia in rheumatic patients from the anemia in the patients with paraneoplastic rheumatic syndromes.

摘要

作者基于短期使用糖皮质激素(泼尼松龙,每天30毫克,持续7 - 10天)的药理负荷结果以及负荷前后在正位X线胸片上对肺部X线影像时间进程的连续评估,描述了一种肺部自身免疫过程的新诊断模式。他考虑了浸润灶和病灶数量及大小的变化以及胸膜和小叶间裂内液体的含量。所提出的负荷方法的应用使得缩短肺部自身免疫疾病的诊断期限并提高诊断准确性成为可能,还能确定糖皮质激素治疗延长的可行性。作者首创的糖皮质激素负荷技术能够根据贫血趋于消退的倾向确定其自身免疫性质,从而确定进一步治疗策略,并区分风湿性患者的自身免疫性贫血与副肿瘤性风湿综合征患者的贫血。

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