引言：P2受体

Introduction: P2 receptors.

作者信息

Burnstock Geoffrey

机构信息

Autonomic Neuroscience Institute, Royal Free and University College, Rowland Hill Street, London NW3 2PF, UK.

出版信息

Curr Top Med Chem. 2004;4(8):793-803. doi: 10.2174/1568026043451014.

DOI:10.2174/1568026043451014

PMID:15078211

Abstract

The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory, urinogenital, gastrointestinal, musculo-skeletal and special sensory diseases, as well as inflammation, cancer and diabetes. Lastly, there are some speculations about future developments in the purinergic signalling field.

摘要

本文描述了配体门控离子通道P2X和G蛋白偶联P2Y受体亚型的当前状态。随后总结了这些受体亚型的分布和作用。文中还探讨了嘌呤能受体的潜在治疗靶点，包括那些与心血管、神经、呼吸、泌尿生殖、胃肠、肌肉骨骼和特殊感觉疾病以及炎症、癌症和糖尿病相关的靶点。最后，对嘌呤能信号领域的未来发展进行了一些推测。