钯催化的1,6-烯炔环化反应生成六元环或氧化五元三氟乙酸酯。
Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates.
作者信息
Mikami Koichi, Hatano Manabu
机构信息
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
出版信息
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5767-9. doi: 10.1073/pnas.0307217101. Epub 2004 Apr 12.
Abstract
We describe palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings by water-originated hydride addition. Mechanistic features of this anomalous carbocyclization and isolation of a chiral five-membered C-Pd intermediate as an oxidized form of trifluoroacetate are also reported.
摘要
我们描述了钯催化的1,6-烯炔的碳环化反应，该反应通过水衍生的氢化物加成生成六元环。还报道了这种异常碳环化的机理特征以及手性五元C-Pd中间体作为三氟乙酸氧化形式的分离。
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