Morgan Gareth
National Public Health Service for Wales, 36 Orchard Street, Swansea SA1 5AQ, UK.
Eur J Public Health. 2004 Mar;14(1):105-6. doi: 10.1093/eurpub/14.1.105.
This paper evaluates aspirin in the reduction of colorectal cancer risk against the nine causality criteria suggested by Bradford-Hill in 1965. Although some questions remain, the evidence is suggestive of a reduction by perhaps 20-30%. Aspirin could make important contributions to public health programmes given that it reduces cardiovascular disease risk and is relatively safe. It is appropriate for bodies such as the World Health Organisation and national governments to begin to consider the future use of aspirin for the reduction of two major sources of death and disability.
本文根据布拉德福德·希尔于1965年提出的九条因果关系标准，评估了阿司匹林在降低结直肠癌风险方面的作用。尽管仍存在一些问题，但证据表明风险可能降低20%-30%。鉴于阿司匹林能降低心血管疾病风险且相对安全，它可为公共卫生项目做出重要贡献。世界卫生组织和各国政府等机构应开始考虑未来使用阿司匹林来降低两大主要死亡和残疾原因的风险。
