Marona Henryk, Szneler Edward
Department of Chemical Technology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str,. 30-688 Kraków, Poland.
Acta Pol Pharm. 2003 Nov-Dec;60(6):477-80.
A series of alkanolamides have been tested for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure treshold (ScMet) assays and for neurotoxicity (TOX) in rodents. Most interesting were the anticonvulsant results of 2N-methylaminoethanol derivative II, which displayed anti-MES activity (mice) with a protective index (TD50/ED50) of 2.536 higher than that for valproate.
一系列链烷醇酰胺已在最大电休克惊厥（MES）和皮下戊四氮惊厥阈值（ScMet）试验中进行了抗惊厥活性测试，并在啮齿动物中进行了神经毒性（TOX）测试。最有趣的是2N-甲基氨基乙醇衍生物II的抗惊厥结果，其显示出抗MES活性（小鼠），保护指数（TD50/ED50）比丙戊酸盐高2.536。
