新型喹唑啉并-β-咔啉-5-酮衍生物的合成及其细胞毒性活性
Synthesis and cytotoxic activity of novel quinazolino-beta-carboline-5-one derivatives.
作者信息
Baruah Bipul, Dasu Kavitha, Vaitilingam Balasubramanian, Mamnoor Premkumar, Venkata Prasanthi Penubaka, Rajagopal Sriram, Yeleswarapu Koteswar Rao
机构信息
Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500050, India.
出版信息
Bioorg Med Chem. 2004 May 1;12(9):1991-4. doi: 10.1016/j.bmc.2004.03.005.
A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts.
合成了一系列新型喹唑啉并-β-咔啉酮衍生物，并对其体外和体内抗癌活性进行了评估。许多化合物在1-8微摩尔浓度范围内表现出良好的体外活性。其中三种化合物在携带HT-29结肠癌异种移植瘤的裸鼠中进一步进行了测试。
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