Kayes J B
J Pharm Pharmacol. 1977 Mar;29(3):163-8. doi: 10.1111/j.2042-7158.1977.tb11275.x.
The microelectrophoretic properties of the drugs griseofulvin, betamethasone, nalidixic acid and thiabendazole in aqueous dispersion have been examined and the zeta potentials calculated from the measured mobilities. Variation in magnitude of particle charge with pH of dispersion is reported and related to the chemical structure and the surface characteristics. The effect of adding anionic (sodium dodecyl sulphate) cationic (dodecyl trimethyl bromide) and non-ionic (polyoxyethylene glycol monoethers of hexadecanol) surface-active agents, and mixtures of these ionic and non-ionic species, on the electrophoretic properties of the drug dispersions has been measured. The results reported agree with those found previously for a model polystyrene latex suspension system under the same conditions.
已对灰黄霉素、倍他米松、萘啶酸和噻苯达唑在水分散体中的微电泳性质进行了研究，并根据测得的迁移率计算了ζ电位。报告了颗粒电荷大小随分散体pH值的变化情况，并将其与化学结构和表面特性相关联。还测定了添加阴离子（十二烷基硫酸钠）、阳离子（十二烷基三甲基溴化铵）和非离子（十六醇聚氧乙烯单醚）表面活性剂以及这些离子和非离子物质的混合物对药物分散体电泳性质的影响。所报告的结果与先前在相同条件下对模型聚苯乙烯胶乳悬浮体系所发现的结果一致。
