Thérien Michel, Skorey Kathryn, Zamboni Robert, Li Chun Sing, Lau Cheuk K, LeRiche Tammy, Linh Truong Vouy, Waddleton Deena, Ramachandran Chidambaram
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Quebec, Pointe Claire--Dorval, Canada H9R 4P8.
Bioorg Med Chem Lett. 2004 May 3;14(9):2319-22. doi: 10.1016/j.bmcl.2004.01.101.
The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.
本文介绍了一种用于蛋白酪氨酸磷酸酶-1B（PTP-1B）酶的新型放射性肽类光亲和探针的合成，以及一些支持选择该化合物作为光亲和探针的构效关系研究。
