Orris L, Shalita A R, Sibulkin D, London S J, Gans E H
Arch Dermatol. 1978 Jul;114(7):1018-20.
In a double-blind controlled comparison that lasted eight weeks, tablets of zinc sulfate monohydrate, 411 mg total daily dosage, and a lactose placebo were administered orally to 22 male subjects with moderate acne. At the same time, levels of zinc were determined in serum and urine. There were no statistically significant differences in the lesion counts (papules, pustules, open comedones, and closed comedones) in the zinc-treated and lactose-treated cases, despite evidence in serum and urine of absorption of zinc. The data from this study indicate that oral zinc therapy has no early clinical effect on male patients with moderate acne.
在一项持续八周的双盲对照比较中，对22名患有中度痤疮的男性受试者口服每日总剂量411毫克的一水硫酸锌片剂和乳糖安慰剂。同时，测定血清和尿液中的锌水平。尽管血清和尿液中有锌吸收的证据，但在接受锌治疗和乳糖治疗的病例中，皮损计数（丘疹、脓疱、开放性粉刺和闭合性粉刺）没有统计学上的显著差异。这项研究的数据表明，口服锌疗法对患有中度痤疮的男性患者没有早期临床效果。
