Hamann Melanie, Richter Angelika
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstrabetae 20, 14195 Berlin, Germany.
Brain Res. 2004 May 15;1008(1):126-30. doi: 10.1016/j.brainres.2004.02.028.
Previous studies suggested that GABAergic dysfunctions within the red nucleus are involved in stress-inducible paroxysmal dystonia of the dt(sz) mutant hamster. In the present study, rubral microinjections of the GABAA receptor agonist muscimol exerted only moderate antidystonic effects and the antagonist bicuculline failed to show significant effects on the severity of dystonia. These data indicate that disturbed rubral GABAergic inhibition is not important for the manifestation of dystonia in the dt(sz) mutant.
先前的研究表明，红核内的γ-氨基丁酸能功能障碍与dt(sz)突变仓鼠的应激诱导性阵发性肌张力障碍有关。在本研究中，向红核微量注射γ-氨基丁酸A受体激动剂蝇蕈醇仅产生中度的抗肌张力障碍作用，而拮抗剂荷包牡丹碱对肌张力障碍的严重程度未显示出显著影响。这些数据表明，红核γ-氨基丁酸能抑制紊乱对dt(sz)突变体中肌张力障碍的表现并不重要。
