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概述:从藤浪晃教授的马匹实验到副肌球蛋白。

Overview: from the horse experimentation by Prof. Akira Fujinami to paramyosin.

作者信息

Kojima Somei

机构信息

JICA-Mahidol University ACIPAC Project, Mahidol University, 3rd Floor Administration Bdg, 420/6 Ratchawithi Road, Bangkok 10400, Thailand.

出版信息

Parasitol Int. 2004 Jun;53(2):151-62. doi: 10.1016/j.parint.2004.01.013.

Abstract

Professor Akira Fujinami demonstrated for the first time in the world that acquired immunity might be induced against macroparasites such as schistosomes. Since then, vaccination models have been developed using various species of animals, among which the attenuated vaccine model in the mouse has been utilized mostly to clarify immune effector mechanisms and define candidate vaccine molecules. However, further studies are necessary on immune responses to defined parasite molecules in humans, because some discrepancies in immune responses still exist between animals and humans, and apparently genetic influence should be taken into consideration in such studies on defined molecules. Despite of some limitations, vaccine trials in livestock against Schistosoma japonicum may provide useful information for development of vaccines against the other human infections caused by S. mansoni or S. haematobium. In this overview, studies carried out mainly by Japanese investigators towards vaccine development will be described.

摘要

藤浪晃教授首次在世界上证明,针对血吸虫等大型寄生虫可能诱导获得性免疫。从那时起,人们利用各种动物开发了疫苗接种模型,其中小鼠减毒疫苗模型大多用于阐明免疫效应机制和确定候选疫苗分子。然而,有必要对人类针对特定寄生虫分子的免疫反应进行进一步研究,因为动物和人类的免疫反应仍存在一些差异,而且在这类针对特定分子的研究中显然应考虑遗传影响。尽管存在一些局限性,但针对日本血吸虫的家畜疫苗试验可能为开发针对曼氏血吸虫或埃及血吸虫引起的其他人类感染的疫苗提供有用信息。在本综述中,将描述主要由日本研究人员开展的疫苗开发研究。

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