Thompson Ian M, Leach Robin, Troyer Dean, Pollock Brad, Naylor Susan, Higgins Betsy
Departments of Surgery and Pathology and Cellular and Structural Biology, University of Texas HSC at San Antonio, The San Antonio Center for Biomarkers of Risk of Prostate Cancer (SABOR), San Antonio Cancer Institute, TX 78229, USA.
Urol Oncol. 2004 Mar-Apr;22(2):127-31. doi: 10.1016/S1078-1439(03)00171-6.
This study was designed to use a prospectively analyzed, population-based, multiethnic cohort of men to determine if there is a relationship between one measure of obesity/overweight (Body Mass Index) and Prostate Specific Antigen (PSA). A total of 1565 men without a prior diagnosis of prostate cancer were prospectively enrolled in the San Antonio study of Biomarkers Of Risk (SABOR) Clinical and Epidemiologic Center of the Early Detection Research Network of the National Cancer Institute. Body Mass Index (BMI) was compared with serum PSA levels, stratifying by ethnic group. No relationship was found between BMI and PSA in any ethnic group or in the cohort as a whole. This study suggests that there is no increased risk of overdetection of prostate cancer among obese men due to an elevation in PSA.
本研究旨在利用一项对男性进行前瞻性分析的、基于人群的多民族队列研究，以确定肥胖/超重的一项指标（体重指数）与前列腺特异性抗原（PSA）之间是否存在关联。共有1565名既往未被诊断为前列腺癌的男性前瞻性纳入了美国国立癌症研究所早期检测研究网络的圣安东尼奥风险生物标志物研究（SABOR）临床与流行病学中心。将体重指数（BMI）与血清PSA水平进行比较，并按种族分组。在任何种族组或整个队列中，均未发现BMI与PSA之间存在关联。本研究表明，肥胖男性不会因PSA升高而增加前列腺癌过度检测的风险。
