Staines Donald R
Gold Coast Public Health Unit, 10-12 Young Street, Southport 4215, Queensland, Australia.
Med Hypotheses. 2004;62(5):670-3. doi: 10.1016/j.mehy.2004.01.006.
Gulf War Syndrome (GWS) remains a contentious diagnosis with conflicting laboratory investigations and lack of a biologically plausible aetiology. Assertions have been made that GWS may be the result of vaccinations given to serving military personnel in the Persian Gulf and may be associated with osteoporosis. Calcitonin gene related protein (CGRP) is a vasoactive neuropeptide that is synthesised in conjunction with calcitonin gene expression. Vasoactive neuropeptides act as hormones, neurotransmitters, immune modulators and neurotrophes. They are readily catalysed to small peptide fragments. They and their binding sites are immunogenic and are known to be associated with a range of autoimmune conditions. This paper describes a biologically plausible mechanism for the development of osteoporosis in the context of GWS based on loss of immunological tolerance to the vasoactive neuropeptide CGRP or its receptors following a variety of antigenic events.
海湾战争综合征（GWS）仍然是一个有争议的诊断，实验室检查结果相互矛盾，且缺乏生物学上合理的病因。有人断言，GWS可能是波斯湾地区现役军人接种疫苗的结果，并且可能与骨质疏松症有关。降钙素基因相关肽（CGRP）是一种血管活性神经肽，它与降钙素基因表达一起合成。血管活性神经肽可作为激素、神经递质、免疫调节剂和神经营养因子。它们很容易被催化成小肽片段。它们及其结合位点具有免疫原性，并且已知与一系列自身免疫性疾病有关。本文描述了在GWS背景下骨质疏松症发生的一种生物学上合理的机制，该机制基于在各种抗原性事件后对血管活性神经肽CGRP或其受体的免疫耐受性丧失。
