Tachibana Tetsuya, Saito Ei-Suke, Saito Shin, Tomonaga Shozo, Denbow Donald Michael, Furuse Mitsuhiro
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812-8581, Japan.
Neurosci Lett. 2004 Apr 29;360(3):165-9. doi: 10.1016/j.neulet.2004.02.055.
Arginine-vasotocin (AVT), a non-mammalian homologue of mammalian arginine-vasopressin, is a stress-related peptide in the brain of birds. The aim of the present study was to determine the effects of intracerebroventricular (ICV) injection of AVT on feeding behavior, body temperature, corticosterone release and several behavioral parameters in chicks. These effects were compared with those of corticotrophin-releasing factor (CRF), another stress-related peptide. The ICV injection of AVT inhibited feeding behavior, increased rectal temperature, and increased plasma corticosterone concentrations, but these effects were weaker than those of CRF. AVT induced hypoactivity as evidenced by decreased vocalization and stepping while CRF induced hyperactivity. The present results demonstrate that some functions of brain AVT are similar to those of CRF, although these effects are weaker than those induced by CRF. However, some AVT-induced behaviors were different from CRF, indicating that the physiological roles of AVT in the regulation of stress behavior are different from those of CRF in chicks.
精氨酸血管加压催产素（AVT）是哺乳动物精氨酸加压素的非哺乳动物同源物，是鸟类大脑中一种与应激相关的肽。本研究的目的是确定脑室内（ICV）注射AVT对雏鸡摄食行为、体温、皮质酮释放及若干行为参数的影响。将这些影响与另一种与应激相关的肽促肾上腺皮质激素释放因子（CRF）的影响进行比较。脑室内注射AVT会抑制摄食行为、升高直肠温度并增加血浆皮质酮浓度，但这些影响比CRF的影响弱。AVT会导致活动减少，表现为发声和踏步减少，而CRF会导致活动增加。目前的结果表明，大脑AVT的某些功能与CRF的功能相似，尽管这些影响比CRF诱导的影响弱。然而，一些由AVT诱导的行为与CRF不同，这表明AVT在雏鸡应激行为调节中的生理作用与CRF不同。
