前促甲状腺激素释放激素信使核糖核酸和促甲状腺激素释放激素存在于大鼠心脏中。
Preprothyrotropin-releasing hormone mRNA and TRH are present in the rat heart.
作者信息
Carnell N E, Feng P, Kim U J, Wilber J F
机构信息
Division of Endocrinology, University of Maryland School of Medicine, Baltimore 21201.
出版信息
Neuropeptides. 1992 Aug;22(4):209-12. doi: 10.1016/0143-4179(92)90047-z.
PreproTRH mRNA has been identified in rat cardiac tissues by Northern analyses and RNase protection assays with a specific rat 32P-TRH cRNA probe. Densitometric analyses revealed that atrial ppTRH mRNA concentrations were approximately five-fold greater than those of the ventricles. TRH concentrations (RIA), by contrast, were two-fold higher in ventricles. These data suggest that TRH and TRH mRNA are present in the rat heart, but their concentrations are dissociated, possibly because of differential post-transcriptional or post-translational processing. TRH is postulated to play an autocrine or paracrine role in cardiac physiology.
通过Northern分析和用特异性大鼠32P-TRH cRNA探针进行的核糖核酸酶保护试验，已在大鼠心脏组织中鉴定出前促甲状腺激素释放激素（PreproTRH）mRNA。光密度分析显示，心房中ppTRH mRNA浓度约为心室的五倍。相比之下，心室中的促甲状腺激素释放激素（TRH）浓度（放射免疫分析）则高出两倍。这些数据表明，TRH和TRH mRNA存在于大鼠心脏中，但它们的浓度是分离的，这可能是由于转录后或翻译后加工的差异所致。据推测，TRH在心脏生理学中发挥自分泌或旁分泌作用。
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