[Dynamics in the content of neuromediators in amine-containing structures during development of tooth hard tissues].

Using luminescent-histochemical methods the contents of neurotransmitters (catecholamines, serotonin, histamine) was determined during the development of dental hard tissues in man. In the dental papilla the luminescent blood vessels were initially demonstrated, while single nerve fibers branching around the odontoblasts appeared later. It was found that enamel organ differentiation at the early stages took place without the participation of granular luminescent cells and mast cells. These cells appeared starting at week 22 of fetal development. Their appearance coincided with the process of enameloblast and odontoblast differentiation. The contents of neurotransmitters in the dental structures studied was found to increase with the fetal age.