Ide K, Momoi Y, Minegishi M, Sekiguchi M, Konno K, Iwasaki T
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Aust Vet J. 2003 Jan-Feb;81(1-2):47-9. doi: 10.1111/j.1751-0813.2003.tb11423.x.
An 8-year-old female Shih Tzu was presented with weight loss and vomiting. Alanine aminotransferase was high and abdominal radiographs revealed hepato- and splenomegaly. Mild anaemia, neutrophilia with left shift, eosinophilia, a thrombocytosis with dysplastic features of eosinophils and platelets, were detected. The animal was initially considered to have hepatitis and was treated accordingly, but clinical signs persisted. Histological examination of liver biopsy samples showed disruption of the hepatic lobule, with extensive infiltration by haemopoietic cells. Further investigation of the bone marrow suggested a diagnosis of myelodysplastic syndrome. The animal was treated with cytarabine ocfosfate, a prodrug of cytosine arabinoside, and appeared to recover.
一只8岁雌性西施犬出现体重减轻和呕吐症状。丙氨酸转氨酶升高，腹部X光片显示肝脏和脾脏肿大。检测到轻度贫血、伴有核左移的中性粒细胞增多、嗜酸性粒细胞增多、具有嗜酸性粒细胞和血小板发育异常特征的血小板增多。该动物最初被认为患有肝炎并接受了相应治疗，但临床症状持续存在。肝脏活检样本的组织学检查显示肝小叶破坏，有造血细胞广泛浸润。对骨髓的进一步检查提示诊断为骨髓增生异常综合征。该动物接受了阿糖胞苷奥磷酯（阿糖胞苷的前体药物）治疗，似乎有所康复。
