Gejyo Fumitake, Kawaguchi Yoshindo, Hara Shigeko, Nakazawa Ryoichi, Azuma Nakanobu, Ogawa Hiroshi, Koda Yutaka, Suzuki Masashi, Kaneda Hiroshi, Kishimoto Hidefumi, Oda Mizue, Ei Kyoko, Miyazaki Ryoichi, Maruyama Hiroki, Arakawa Masaaki, Hara Mitsuru
Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Artif Organs. 2004 Apr;28(4):371-80. doi: 10.1111/j.1525-1594.2004.47260.x.
We investigated the clinical efficacy of direct hemoperfusion with a beta2-microglobulin (beta2-m) adsorption column for the treatment of patients with dialysis-related amyloidosis. A 2-year prospective controlled study was performed to compare the effects of passaging blood through a (beta2-m) adsorption column (Lixelle) before it is passaged through the dialysis polysulfone membrane on the severity of amyloidosis in these individuals. Patients (n = 22) whose blood went through the Lixelle column prior to dialysis had a higher beta2-m removal rate compared to an equal number of controls, and they showed earlier improvement in their symptoms which included impaired daily activities, joint stiffness, and pain. The appearance of additional bone cysts was prevented in pre-adsorbed patients but not in the controls. Thus, the Lixelle column is useful in preventing the progression of dialysis-related amyloidosis and in ameliorating or arresting the progression of the symptoms of this disorder.
我们研究了使用β2-微球蛋白（β2-m）吸附柱进行直接血液灌流治疗透析相关性淀粉样变性患者的临床疗效。进行了一项为期2年的前瞻性对照研究，以比较在血液通过透析聚砜膜之前先通过（β2-m）吸附柱（Lixelle）对这些个体淀粉样变性严重程度的影响。与同等数量的对照组相比，在透析前血液通过Lixelle柱的患者（n = 22）具有更高的β2-m清除率，并且他们的症状改善更早，这些症状包括日常活动受损、关节僵硬和疼痛。预先吸附的患者中额外骨囊肿的出现得到了预防，而对照组中则没有。因此，Lixelle柱有助于预防透析相关性淀粉样变性的进展，并改善或阻止该疾病症状的进展。
