Ohshima Tadashi, Yamaguchi Taketo, Ishihara Takeshi, Yoshikawa Masaharu, Kobayashi Akitoshi, Sakaue Nobuyuki, Baba Takeshi, Yamada Syuji, Saisho Hiromitsu
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Pancreas. 2004 Apr;28(3):335-43. doi: 10.1097/00006676-200404000-00024.
Tumor vascularization has been attracting attention. However, there have been only a few reports on tumor vascularization in pancreatic ductal carcinoma, especially on vascularization depicted by imaging modalities. We investigated the relationship among wide-band Doppler signals, clinicopathological factors, and vascular endothelial growth factor (VEGF) expression.
Sixty-nine patients with pancreatic ductal carcinoma were investigated. The vascular signals from carcinoma lesions were assessed by contrast-enhanced, wide-band Doppler ultrasonography (dynamic flow). VEGF expression was quantitated by enzyme immunoassay for 28 patients. Depending on the intensity of the signals, the patients were classified into type A (definite vascular signal) or type B (almost no vascular signal).
Type A patients and type B patients accounted for 65% and 35% of patients, respectively. According to multivariate analysis of vascular signal type and clinicopathological factors, liver metastasis occurred significantly more frequently in the type A group. VEGF expression was also significantly higher in the type A group than in the type B group.
Dynamic flow has very high sensitivity for detecting the vascular signals from pancreatic ductal carcinoma. The quantity of vascular signals correlated with tumor characteristics and VEGF.
肿瘤血管生成一直备受关注。然而，关于胰腺导管癌肿瘤血管生成的报道较少，尤其是关于成像方式所显示的血管生成。我们研究了宽带多普勒信号、临床病理因素与血管内皮生长因子（VEGF）表达之间的关系。
对69例胰腺导管癌患者进行研究。通过对比增强宽带多普勒超声（动态血流）评估癌灶的血管信号。对28例患者采用酶免疫分析法对VEGF表达进行定量分析。根据信号强度，将患者分为A型（明确血管信号）或B型（几乎无血管信号）。
A型患者和B型患者分别占患者总数的65%和35%。根据血管信号类型与临床病理因素的多因素分析，A型组肝转移的发生率明显更高。A型组的VEGF表达也明显高于B型组。
动态血流对检测胰腺导管癌的血管信号具有很高的敏感性。血管信号的数量与肿瘤特征和VEGF相关。
