Diaz-Arias A A, Bickel J T, Loy T S, Croll G H, Puckett C L, Havey A D
Department of Pathology, School of Medicine, University of Missouri, Columbia.
Oral Surg Oral Med Oral Pathol. 1992 Aug;74(2):206-11. doi: 10.1016/0030-4220(92)90384-3.
A case of follicular carcinoma arising in the lingual thyroid of a 23-year-old woman is added to the 22 previous reports. The embryology and the clinical and pathologic differential diagnoses are discussed. Histologic criteria useful in diagnosing follicular malignancy in this area include local and vascular invasiveness, hypercellularity, mitotic activity, and necrosis. The use of the immunohistochemical marker thyroglobulin and electron microscopy are described for the first time and confirm a thyroid follicular cell origin.
一位23岁女性舌甲状腺发生滤泡癌的病例被补充到之前的22份报告中。文中讨论了其胚胎学以及临床和病理鉴别诊断。有助于诊断该区域滤泡性恶性肿瘤的组织学标准包括局部和血管浸润、细胞增多、有丝分裂活性和坏死。首次描述了免疫组化标志物甲状腺球蛋白的应用及电子显微镜检查，证实其起源于甲状腺滤泡细胞。
